Vfend (Voriconazole) 200mg by 28 Tablets

Vfend is an antifungal medication containing voriconazole as its active ingredient. It is presented in the form of tablets, each containing 200mg of voriconazole. Voriconazole belongs to the triazole class of antifungal agents and works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thus exerting its antifungal effects.

Uses:

1. Treatment of Serious Fungal Infections:

   • Invasive Aspergillosis: A severe infection caused by Aspergillus species, primarily affecting immunocompromised individuals.
   • Candidemia (Non-Neutropenic Patients): Bloodstream infections caused by Candida species.
   • Esophageal Candidiasis: Infection of the esophagus by Candida species.
   • Scedosporium apiospermum and Fusarium spp. Infections: Serious infections caused by these rare, but often resistant, fungi.

2. Treatment of Other Severe Mycoses:

   • Endemic Mycoses: Such as coccidioidomycosis, histoplasmosis, and blastomycosis, especially in cases where first-line antifungals are ineffective or not tolerated.

3. Prophylaxis in High-Risk Patients:

   • Bone Marrow Transplant Recipients: To prevent fungal infections in patients undergoing bone marrow transplantation who are at high risk for invasive fungal infections.

Administration and Dosage:

• The typical dosage is 200mg taken orally every 12 hours. Dosage adjustments may be necessary based on the severity of the infection, patient response, and tolerability.
• Tablets should be taken at least one hour before or one hour after meals to ensure optimal absorption.

Effectiveness:

• Vfend is highly effective in treating a broad spectrum of fungal infections, particularly those caused by Aspergillus and Candida species.
• It is often used when other antifungal treatments have failed or when patients are intolerant to other therapies.