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Sayana Press is a prescription-only, long-acting hormonal contraceptive injection. It is supplied as a single-dose, all-in-one Uniject™ prefilled injection system containing 104mg of Medroxyprogesterone Acetate suspended in 0.65mL of sterile liquid.
It is administered via a Subcutaneous (S.C.) injection into the fat layer under the skin. It provides exceptionally reliable, reversible birth control, with each single injection successfully preventing pregnancy for 13 consecutive weeks (3 months). Because of its unique, easy-to-use prefilled design, it can be administered at home by the patient herself or a caregiver after proper clinical training.
Once injected into the subcutaneous fat layer, the medication creates a microscopic hormone reservoir that slowly and continuously releases a progestin hormone into your bloodstream:
Inhibits Ovulation: Its primary mechanism is to temporarily stop the ovaries from developing and releasing a mature egg each month. If there is no egg released, fertilization cannot take place.
Thickens Cervical Mucus: It thickens the natural mucus at the opening of the womb (cervix), acting as a thick physical barrier that prevents sperm from traveling into the uterus.
Alters the Uterine Lining: It thins the internal lining of the womb (endometrium), making it highly unfavorable for an egg to attach.
Long-Term Contraception: Prevention of pregnancy for up to 13 consecutive weeks per injection. It is over 99% effective, making it one of the most reliable reversible birth control options available.
A healthcare provider will review your medical profile before approving the injection to rule out specific risk factors:
Pregnancy: Sayana Press must strictly never be administered if you are pregnant or suspect you might be.
Severe Cardiovascular Disease: Avoid if you have an active history of severe blood clots (like Deep Vein Thrombosis—DVT or a pulmonary embolism), a history of strokes, or severe heart disease.
Hormone-Sensitive Cancers: Active or past history of breast cancer or other malignancies sensitive to progesterone hormones.
Severe Liver Impairment: Avoid if you have advanced liver disease or active liver tumors, as the liver processes this hormone.
Unexplained Vaginal Bleeding: If you have unusual vaginal bleeding that has not yet been evaluated and diagnosed by a doctor, the injection must be delayed.
The 13-Week Calendar Law: You must receive your follow-up Sayana Press injection exactly every 13 weeks (91 days). To ensure you do not lose your pregnancy protection, you can take it up to 1 week early or up to 1 week late (between weeks 12 and 14). If you are more than 1 week late, you must confirm a negative pregnancy test and use a backup barrier method (like condoms) for 7 days after the shot.
The Mixing Rule: The active medicine settles to the bottom of the plastic bulb during storage. You must shake the prefilled syringe vigorously for at least 30 seconds before use to mix the liquid into a completely uniform, white, milky suspension. If it remains separated, do not inject it.
Do Not Massage the Site: After pressing the plunger to deliver the medicine beneath the skin, gently press a clean cotton ball on the site for a few seconds. Never rub or massage the injection site, as massaging causes the medicine to absorb too quickly, reducing how long it protects you.
1.Warm the device and shake vigorously:Temperature & Mix.
Let the prefilled device sit at room temperature for a few minutes. Shake it hard for at least 30 seconds until it turns into a uniform, milky white liquid.
2.Press the needle cap to activate the device:Activation.
Hold the device by the plastic collar, press the needle cap firmly down into the main body until it clicks, then pull the cap off to expose the needle.
3.Pinch the skin and squeeze the bulb firmly:Injection Mechanics.
Clean the skin (abdomen or thigh) with an alcohol swab. Pinch a fold of skin, insert the needle straight in at a 90-degree angle, and squeeze the plastic bulb firmly over 5 to 7 seconds.
4.Discard the system into a sharps bin:Safe Disposal.
Withdraw the needle smoothly and place the used single-use Uniject system immediately into a puncture-proof sharps disposal bin.
As your system adjusts to the low-dose release of the progestin hormone, you may notice typical updates:
Changes in Bleeding Patterns: Highly common during the first 6 to 12 months. You may experience unpredictable spotting, irregular tracking, or light bleeding between periods. Over time, your periods will become significantly lighter or may stop completely (amenorrhea), which is a completely safe and expected reaction.
The Bone Mineral Density Note: Long-term use of medroxyprogesterone acetate can cause a slight, temporary thinning of your bones (loss of bone mineral density). This loss standardly stops and reverses back to normal once you stop using the injection. Ensure you get adequate Calcium and Vitamin D daily.
Minor redness, slight swelling, or mild itching at the skin site where the needle entered.
Mild hormonal shifts, including temporary weight changes, breast tenderness, mild headaches, or minor skin changes.
Does Sayana Press protect against Sexually Transmitted Infections (STIs)?
No. Sayana Press protects strictly against pregnancy; it does not protect against STIs or HIV. To protect yourself from infections, you must use barrier methods, such as latex condoms, during every sexual encounter alongside your contraceptive injection.
How quickly does Sayana Press start working?
If you receive your very first injection during the first 5 days of a normal menstrual cycle, it begins protecting you against pregnancy immediately. If it is given on any other day of your cycle, you must use a backup non-hormonal barrier method (like condoms) for 7 consecutive days after the shot to allow the hormone levels to build up securely.
How long does it take for my fertility to return after stopping the injections?
Because the hormone reservoir clears out of the subcutaneous tissue slowly over time, it takes longer for your natural ovulation cycles to return compared to daily pills. On average, it can take 6 to 10 months after your last scheduled injection window for your regular periods and full fertility to return when planning a pregnancy.
Specialized subcutaneous contraceptives and prefilled self-injection systems require continuous climate-controlled storage ($15^{\circ}\text{C}$ to $30^{\circ}\text{C}$—never refrigerated or frozen), strict packaging seals, and trusted supply chain tracking to guarantee hormone stability and protect treatment success. You can submit your physician's or gynecologist's prescription and buy genuine, factory-authenticated Sayana Press Injection systems online through Sanlive Pharmacy & Stores for secure payment and fast, reliable same-day delivery directly to your home, office, or clinical suite within Lagos, Abuja, and Port Harcourt. We also provide nationwide delivery through our trusted specialty logistics partners to deliver your essential reproductive health care safely anywhere in Nigeria.
Important Notice: This information is for educational support purposes only. Sayana Press is a prescription-only hormonal contraceptive system. While it is designed for convenient home use, your very first injection, clinical assessment, and initial self-injection training must be guided under the direct supervision of a registered Gynecologist, trained physician, or certified nurse-midwife. If you experience sudden severe lower abdominal pain, a severe or unusual headache, yellowing of your eyes or skin, sudden swelling and severe pain in one calf, or signs of a severe allergic reaction, seek immediate medical evaluation at a hospital.
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